EFFICACY OF LIVE ATTENUATED FOWL ADENOVIRUS SEROTYPE 8B ISOLATE OF MALAYSIA IN SPECIFIC PATHOGEN-FREE CHICKENS

Fowl adenovirus (FAdV) is the primary agent of inclusion body hepatitis (IBH) in poultry and caused serious economic impact due to high mortality poor productivity. To date, clinical cases IBH chickens increases over years Malaysia, thus, an effective local vaccine control disease outbreak dire need. The objective study was determine efficacy live attenuated FAdV serotype 8b isolate, UPM1137CEL35, specific-pathogen-free chickens. Attenuated isolate UPM1137CEL35 conferred full protection against virulent UPM11134 vaccinated Neither signs nor were recorded all groups. However, challenged unvaccinated group, showed weakness, reduced feed consumption, lateral recumbency at day 4 7 postchallenge. Additionally, weight low significantly (p<0.05) compared Upon necropsy, liver from group pale peripheral bilateral lobes with presence focal lymphoid aggregation microscopically, while, groups normal without significant changes. All protected manifestations antibody response group. It concluded that has a potential be used as Malaysian isolates.